Members of Sudan's transitional government and other civilian leaders have been arrested amid reports of a military coup.
Prime Minister Abdallah Hamdok is among those reported to have been put under house arrest by unidentified soldiers.
The army has not commented, but pro-democracy groups urged street protests.
Military and civilian leaders have been at odds since long-time ruler Omar al-Bashir was overthrown two years ago and the transitional government set up.
It remains unclear who was behind the pre-dawn arrests.
A statement from the information ministry on Facebook said the detentions were carried out by "joint military forces" and those arrested were being held in "an unidentified location".
It said Hamdok was being pressed to support a coup but was refusing to do so and he urged people to continue with peaceful protests to "defend the revolution".
The United States was "deeply alarmed" by the coup reports, its special envoy for the Horn of Africa, Jeffrey Feltman, said.
Witnesses have said that the internet is down in the capital, Khartoum, while images have appeared on social media showing angry crowds burning tyres in the streets.
The army and paramilitary have been deployed across the city, restricting the movement of civilians, a witness is quoted as saying by Reuters news agency.
Khartoum airport is now closed, and international flights are suspended.
Sudan's main pro-democracy group has called on its supporters to resist any military coup.
The military and civilian transitional authorities have ruled together since President Bashir was toppled after months of street protests in 2019.
A power-sharing deal between the military and a loose coalition of groups - the Forces for Freedom and Change (FFC) - had been agreed, launching the Sovereign Council.
It was to rule the country for another year - with the aim of holding elections and transitioning to civilian rule.
But the deal has always been fractious, with a large number of rival political groups - and divisions within the military too.
Tensions grew further after a coup attempt attributed to followers of Bashir was foiled in September.
This month, opponents of Sudan's transition to democracy took to the streets of Khartoum to call on the army to take control of the country.
Pro-democracy groups said it was an organised attempt by the military to retake power.
Last Thursday, tens of thousands of people demonstrated in Khartoum to show solidarity with the transitional government.
Support for the interim government has slumped in recent months as the country's economy has struggled.
Sudan has been unable to find a workable political system since independence in 1956 and has seen numerous coups and coup attempts.
PM well respected
Hamdok is an economist and former senior UN official who was appointed as a technocratic prime minister in 2019 and is well respected internationally.
Though popular with pro-democracy civilian groups, he has struggled to keep the transition going due to political splits between the military and civilians and the pressures of an economic crisis.
Family sources told Reuters that military forces had stormed the house of Hamdok's media adviser and arrested him.
The Sudanese Professionals Association, a main activist coalition in the uprising against Bashir, called on supporters to mobilise after what it called the arrest of cabinet members.
"We urge the masses to go out on the streets and occupy them, close all roads with barricades, stage a general labour strike, and not to cooperate with the putschists and use civil disobedience to confront them," the group said in a statement on Facebook.
-BBC / Reuters