A report on Whānau Ora shows its roll-out has been variable and there has been a lack of money funding in some areas, a Māori health advocate says.
Sir Mason said that while Whānau Ora was "by-and-large" meeting its goals, there was still no integrated whole-of-Government approach - which was needed urgently.
The report also found that inefficient funding and contracting structures made some change difficult - and Sir Mason Durie agreed.
"That's fair comment. It's been easier for community groups to collaborate than for different departments in the ministry to collaborate and yet this is a whole of government programme - should be - and that really creates an onus for government departments to be able to work together to get a common vision and a common agenda that will produce benefits to whānau."
Sir Mason said a lack of Government framework meant the different sectors that could be collaborating on the Whānau Ora initiative - social, economic, cultural and environmental - continued to work in silos.
"What hasn't come through as strong is how Government can develop a framework that would facilitate integrated development."
He said more urgency was needed to address the issue.
"It's about 50-years-old, the urgency. We can get locked into sectors - people don't live their lives in sectors," he said.