The Wales and Lions fullback Lee Byrne will miss the opening three rugby Tests of next month's campaign against Australia, South Africa and Fiji.
The Ospreys star fractured the third metacarpal in his right hand during yesterday's Magners League clash against Glasgow.
The Welsh Rugby Union say Byrne has an outside chance of being available for the finale against New Zealand on November the 27th.
The Cardiff Blues back Chris Czekaj has been called into the squad as a replacement for Byrne, while Scarlets backrow forward Rob McCusker has withdrawn from the squad to undergo a hernia operation.