South Africa's trounced Australia by an innings and 80 to win the second cricket in Hobart and seal the three match series with a a game to spare.
South Africa's pace bowlers tore through Australia's last eight wickets before lunch on day four to inflict a humiliating loss on Australia.
Faf du Plessis has described his side's performance in the second test as relentless. Photo: Photosport
The home side had resumed their second innings on 121-2, with hope of saving the match on an overcast day at Bellerive Oval, but their batsmen crumbled to 161 all out, losing their last eight wickets for just 40 runs.
Only three Australian batsmen reached double figures.
Resurgent South Africa won the series-opener in Perth by 177 runs and will head into their first day-night test match in Adelaide next week confident they can sweep their demoralised opponents.
It was their third straight test series win in Australia after their 2008 and 2012 successes.
Australia, meanwhile, face another bout of soul-searching, having slipped to a fifth consecutive test defeat after losing their first match of the home summer in 28 years in Perth.
"For us it was just about trying to fight and spend some time out in the middle," said Australia captain Steve Smith, who was caught behind off Kagiso Rabada for 31.
"It wasn't the way we planned it, credit to South Africa I thought they bowled beautifully again this morning."
Man of the Match Kyle Abbott, the replacement for injured spearhead Dale Steyn, finished with 6-77, capturing four wickets in the morning session and triggering a stunning collapse that followed the home side's 85 in the first innings.
Rising talent Rabada completed the rout with 4-34, following on from his five-wicket haul at the WACA.
"All our bowlers were exceptional," said Proteas skipper Faf du Plessis.
"I'm so happy for Kyle ... every single time he gets an opportunity he puts his hand up."