All Blacks centre Sonny Bill Williams has failed to make the Chiefs lineup for Sunday morning's Super Rugby clash with the Sharks in Durban.
Williams suffered a head knock in last weekend's win over the Stormers in Cape Town.
While he passed a concussion test at the time, he was suffering from head aches earlier this week.
The Chiefs say Williams has been clear from symptoms after his head-knock, but ran out of time to fulfill the protocol system.
Chiefs coach Dave Rennie has made four changes to the starting XV.
Props Jamie Mackintosh and Siate Tokolahi will start, after they provided great impact when they came off the bench last week.
As expected there is a new midfield combination with Andrew Horrell and Seta Tamanivalu taking over the duties from the injured Tim Nanai-Williams and Sonny Bill Williams.
There have been six changes to the reserves. Forwards Rhys Marshall, Ben Tameifuna, Mitchell Graham and Johan Bardoul join back Hosea Gear as new additions to the pine.
The match will be played on Saturday 21 March at 7.10pm local time (Sunday 22 March 6.10am New Zealand time).
1. Jamie Mackintsoh
2. Hika Elliot
3. Siate Tokolahi
4. Matt Symons
5. Michael Fitzgerald
6. Liam Messam ©
7. Sam Cane
8. Michael Leitch
9. Brad Weber
10. Aaron Cruden
11. James Lowe
12. Andrew Horrell
13. Seta Tamanivalu
14. Bryce Heem
15. Damian McKenzie
16. Rhys Marshall
17. Ben Tameifuna
18. Mitchell Graham
19. Michael Allardice
20. Johan Bardoul
21. Augustine Pulu
22. Tom Marshall
23. Hosea Gear