United States officials will head a roundtable at the Pacific Islands Forum with regional leaders to discuss various issues facing the members.
Senior US officials will travel to Nauru with Secretary of the Interior Ryan Zinke for the September 4 talks.
A Department of State spokesperson said they will discuss combating illegal fishing, responding to the threat of North Korea and promoting sustainable development.
In recent weeks Washington has announced funding totalling $US413 million into the Indo-Pacific region.
While the United States is not a member of the Pacific Islands Forum, it is one of several dialogue partners.