The Hurricanes pair of Jack Lam and Alapati Leiua will debut for Samoa in the four-nation rugby tournament test against Scotland in South Africa.
The Pacific Islanders feature in the first half of a Durban international double-header with South Africa meeting Italy in the main attraction at Kings Park.
Lam and Leiua are among nine changes to the team beaten 22-14 by France in the last Samoan Test appearance seven months ago.
Centre Johnny Leota, fly-half Tusi Pisi, tight-head prop Census Johnston, lock Filo Paulo, flanker Ofiso Treviranus and No.8 Taiasina Tuifu'a survive from the Paris starting line-up.
Paul Williams, a son of All Blacks wing legend Bryan Williams, was chosen at outside centre after playing at fullback last weekend in a 74-14 thrashing from South African province Golden Lions.
After the Scottish Test, Samoa play Italy in Nelspruit and then a tournament classification match in Pretoria.