Asaeli Tikoirotuma has replaced the suspended Nemani Nadolo on the left wing for Fiji's crucial Pool A clash with Wales on Friday morning.
Nadolo was banned for one week for a dangerous tip tackle in last week's defeat to Australia.
Fiji winger Aseli Tikoirotuma looks for support in their 2015 Rugby World Cup match against Australia. Photo: AFP
Head coach John McKee has made five other changes to the run-on team, which is Fiji's most experienced starting fifteen ever at a Rugby World Cup with 392 caps.
Timoci Nagusa starts on the right wing, just days after replacing the injured Waisea Nayacalevu in the Fiji squad.
Lepani Botia will make his Rugby World Cup debut at second five, in place of Gabiriele Lovobalavu, while Nemia Kenatale gets his first start of the tournament at halfback after Nikola Matawalu suffered bruising to his lower back.
In the forwards, Sunia Koto comes in at hooker while Dominiko Waqaniburotu returns from suspension on the blindside flank.
Fiji assistant coach Tabai Matson said it had been a difficult start to the tournament, following losses to England and Australia, but the team remained upbeat.
"The mountain just got steeper - now we're relying on other people to fall over - so it's business as usual for us but, clearly when you play the world-ranked teams two, three and four in 13 days, it was always going to be a tough month for us.
"In saying that, we're still enjoying ourselves and we know we've got a great opportunity still in front of us and we're really excited about the Welsh game coming up".
Captain Akapusi Qera will also win his 50th test cap at the Millenium Stadium.
Fiji squad:
1. Campese Ma'afu
2. Sunia Koto
3. Manasa Saulo
4. Tevita Cavubati
5. Leone Nakarawa
6. Dominiko Waqaniburotu
7. Akapusi Qera (Captain)
8. Netani Talei
9. Nemia Kenatale
10. Ben Volavola
11. Aseli Tikoirotuma
12. Lepani Botia
13. Vereniki Goneva
14. Timoci Nagusa
15. Metuisela Talebula
Replacements:
16. Viliame Veikoso
17. Peni Ravia
18. Leeroy Atalifo
19. Nemia Soqeta
20. Malakai Ravulo
21. Henry Seniloli
22. Joshua Matavesi
23. Kini Murimurivalu