Venus Williams upset 16th-ranked Russian Veronika Kudermetova 6-4 7-5 at the Cincinnati Open, her first win over a top-20 opponent in four years, as unseeded American compatriot Sloane Stephens overcame a sluggish start to beat Italy's Elisabetta Cocciaretto 7-5 6-2.
Williams used all of her veteran composure as she overcame deficits in both sets and converted six of nine break points.
The 43-year-old initially appeared outmatched at the hard court tournament as Kudermetova broke in the first and fifth games but mounted an extraordinary comeback to win the final five games in a row to claim the first set.
Kudermetova flipped the momentum as she won the next four straight and nearly closed out the second set in the eighth game but instead helped Williams to break with a double fault and a pair of unforced errors.
The Russian missed another opportunity to win the second set when Williams fended off a break point in the ninth game with an unreturnable serve.
Seven times Grand Slam winner Williams had the momentum as she converted a break point in the 10th game and a demoralised Kudermetova handed her the match with a pair of double faults - out of nine across the entire match - in the final game.
Stephens, who along with Cocciaretto was unable to get a full warm-up in due to rain that delayed the start of the match, broke the Italian five times and saved three of five break points en route to sealing the win in 76 minutes.
She will next face French defending champion Caroline Garcia in the second round.
"I felt like when I came out here I was a little bit slow and obviously she didn't get to do her full warm-up, and our warm-up it was raining at the end," world number 38 Stephens said in her on-court interview. "So a lot drama but happy to be through after a slow start."
Cocciaretto took control early on and built a 5-2 lead that gave her two chances to serve out the set but Stephens dialled up the pace and broke to love on each occasion as she used a five-game winning streak to wrap up the opening set.
In the second, Stephens kept her foot on the gas as she consolidated an early break with a hold to love for a 3-0 lead before going on to end the encounter with another service break.
Stephens can expect a tougher test against sixth seed Garcia, who is 4-2 all-time versus the American including a pair of first-round wins at the Cincinnati Open.
Stephens won their most recent encounter at Guadalajara in 2022.
-Reuters