The first person diagnosed with ebola in the United States, Thomas Eric Duncan, has died in a Dallas hospital, the BBC reports.
Duncan became ill with the haemorrhagic fever after arriving in the Texas city from Liberia on 20 September to visit family.
Duncan, who caught the virus in his native Liberia, was being kept in isolation in a Dallas hospital and receiving experimental drugs.
Earlier the US announced new screening measures at entry points to check travellers for symptoms of the virus.
More than 3,500 people have died and 7,500 infected, mostly in West Africa, in the worst ebola outbreak yet.
Duncan, who worked as a driver for a courier company, tested positive in Dallas, Texas, on 30 September, 10 days after arriving on a flight from Monrovia via Brussels.